4 edition of Variability in Human Drug Response found in the catalog.
July 1, 1999
by Elsevier Science Pub Co
Written in English
|Contributions||Fundacion Dr. Antonio Esteve Symposium 1998 (Corporate Author), Geoffrey T. Tucker (Editor)|
|The Physical Object|
|Number of Pages||316|
Europe PMC is an ELIXIR Core Data Resource Learn more >. Europe PMC is a service of the Europe PMC Funders' Group, in partnership with the European Bioinformatics Institute; and in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine (NCBI/NLM).It includes content provided to the PMC International archive by participating publishers. Inter individual Variability in Drug Response Disease Drug Class Rate of Poor Response Asthma Beta-agonists % Hypertension Various 30% Solid Cancers Various 70% Depression SSRIs, tricyclics % Diabetes Sulfonylureas, others 50% Arthritis NSAIDs, COX-2 inhibitors % Schizophrenia Various %
Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco-+ genomics) reflects its combining of pharmacology and cogenomics analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or. Variability in Human Drug Response. (PMCID:PMC) Full Text Citations ; BioEntities ; Related Articles ; External Links ; Proc R Soc Med. June; 67(6 Pt 1): – PMCID: PMC Variability in Human Drug Response. Reviewed by Alan Richens.
Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular patient. Recent advances provide a rational framework for understanding.
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Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and Edition: 1. Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration.
This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion. The sensitivity of tissues of the body to drugs and the importance of monitoring.
Variability in the human drug response Thromb Res Suppl. ; doi: /(83) Author G D Sweeney. PMID: DOI: /(83) Abstract Variations in response to drugs may be pharmacodynamic, implying inter-individual differences in the response of receptors in equal concentrations of drug, or Cited by: 8.
Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion.
If the dose response relationship for the drug in question is not steep, or if the therapeutic index is low, drug concentration in the region of the receptor will not be critical and causes of kinetic variation are unlikely to be clinically significant.
However, it is the many causes of kinetic variation Cited by: 8. The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability.
Six chapters address variability of drug metabolism in vivo: variability of. If an exam candidate is for whatever reason unwilling to get hold of the official exam textbook, but somehow willing to buy another textbook, a suitable one might be Variability in human drug response by Smith and Rawlins ().
Given the near-total lack of SAQs on this topic in the past papers, reading this page text would probably be a. Variability in Human Drug Response G.T. Tucker, Editor Variability in human drug response.
Age as a source of variability Mark T. Kinirons Clinical Age Research Unit, Guy's, King's & St Thomas' School of Medicine, Dentistry & Biomedical Science, London, United Kingdom. ABSTRACT. Variation in the response to equivalent drug concentrations arises because of various factors, such as differences in receptor number and structure, receptor-coupling mechanisms and physiological changes in target organs resulting from differences in genetics, age and health.
For example, the beneficial natriuresis produced by the loop diuretic. The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans.
Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability.
Additional Physical Format: Online version: Smith, Stephen E. (Stephen Edward), Variability in human drug response. London: Butterworth, Human populations express significant genetic polymorphism. This polymorphism extends to drug receptor targets, secondary messenger system and other homeostatic or regulatory pathways.
Pharmacogenetics is the study of variability in drug response due to these inherited features. Examples of pharmacogenetic disorders include malignant hyperthermia, G6PD, porphyria and atypical plasma.
Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.
Based on 60, human exomes from the ExAC dataset, we performed an in-depth computational analysis of the prevalence of functional. Changes in components of the response distal to the receptor Although a drug initiates a response by binding to receptors, the response is dependent on the functional integrity of the biological system and associated cellular and physiological responses.
Physiological and pathological states may lead to variability of response. Absorption. Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions.
Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic variants in genes encoding proteins involved in drug metabolism, transport, and response.
To understand the global. Variability of drug response is also a consequence of a variety of drug interactions which may influence pharmacokinetic parameters.
Among the many factors which are responsible for the variation in human drug response, age is relatively important. As a consequence of impaired metabolism and excretion the inter-individual variation in the.
There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose–exposure–response relationships and can affect the drug residues.
Variability in response to therapy is an expected feature of most drug treatments. Pharmacokinetic variability arises because of variable delivery of a dose of a drug. Individual differences in the response of people to a drug and variability in the response that occurs when patients are given a drug on several occasions are important problems in clinical pharmacology.
Indeed, variability in the responsiveness of all living organisms to toxic chemicals has general importance in biology. Full text Full text is available as a scanned copy of the original print version.
Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by page. Nevertheless, our data indicate that variation in the noncoding regions of these genes, particularly SLC22A8, may have an impact on human variation in handling of drugs and toxins by the.
Variability in the response to drugs is due to three principal components—the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration).
The relative contributions.Variability of drug response • Definitions: Individuals in a population respond differently to drugs -Because animal reproductive studies are not always predictive of human response, most drugs should be used during pregnancy only if clearly needed.
Sources of variability in individual.